Effect of Momordica charantia on Insulin Immune-reactive Pancreatic Beta Cells and Blood Glucose Levels in Streptozotocin-induced Diabetic Rats

The present study was conducted to determine the antidiabetic effect of Momordica charantia on pancreatic islets Langerhans in streptozotocin-induced diabetic male Wistar rats relation distribution insulin immuno-positive beta cells. fed at 2 %, 5 % and 10 standard diet for 12 w. After sacrifice, tissues were obtained histopathological immunohistochemical observations. In addition, monitoring fasting blood glucose applied each month during experimental period. results revealed that oral doses daily increased percentage insulin-positive cells as well size number islets. Moreover, significant (p≤0.01) dose time-dependent reduction levels observed. conclusion, these suggest induces effects via regeneration increase secretory granules; hence, reduction.